- In-house production · Lugo, Spain · Ships to worldwide
- ES
- +34 982 816 715
Precision purification of natural compounds, APIs and impurities through preparative HPLC. From sample receipt to purified material and CoA, managed by a PhD-level analytical team in Lugo, Spain.
CIFGA offers a contract purification service based on extensive experience in the purification of complex mixtures and natural extracts. The service specialises in precision purification through preparative HPLC, targeting purity above 95% where technically feasible with the analytical documentation laboratories need for research, development and regulatory purposes.
All projects are managed with direct communication between client and analyst from initial enquiry through to final delivery. Confidentiality agreements are available before any technical discussion begins.
The service is used by laboratories and organisations across several sectors:
The service covers a broad range of purification objectives:
Sample quantities accepted: 5 mg to 50 g. Laboratories with requirements outside that range are welcome to contact the team to discuss feasibility.
The service is supported by a full suite of chromatographic and spectroscopic instrumentation for both preparative separation and structural characterisation.
NMR Varian 500 MHz and NMR Bruker 750 MHz For NMR analyses: 1H, 13C, DEPT, COSY, HMBC, HSQC. The Bruker 750 MHz provides high-resolution NMR data, supporting structural elucidation, and qNMR purity assignments.
Preparative HPLC System of Waters Autosampler and fraction collector coupled to a Waters 3100 single quadrupole mass detector. Core instrument for preparative separations with mass-directed fraction collection. The system can also be configured with UV or FLD detection.
UPLC Waters Acquity Equipped with XEVO TQMS. Used for UPLC/MS/MS analyses supporting impurity identification and purity confirmation.
HPLC Waters Alliance Equipped with a Waters dual absorbance detector.
Contact the team with details of your compound and purification objective. A confidentiality agreement can be arranged before technical discussions begin.
The team evaluates available options and presents a method strategy with expected purity outcomes. Concept testing is available to assess feasibility before committing to a full run, particularly useful when working with novel or complex starting materials.. A timeline and quote are sent for client approval.
Samples are sent to CIFGA’s facility in Lugo, Spain. Required quantity: 5 mg to 50 g. Please provide information on sample condition, solubility, handling requirements and any known toxicity before dispatch.
The team runs the purification and maintains direct contact with the client throughout. The service typically targets purity above 95%, depending on sample complexity and project feasibility. Specific purity requirements can be agreed at the evaluation stage.
The client is welcome to contact the team at any stage of the process.
Purified material is returned with an analysis report or Certificate of Analysis (CoA) documenting purity, structural identity and the analytical methods used.
A typical impurity isolation project illustrates the process: a synthesis product containing a target compound at 60–70% purity in a complex matrix is received, a preparative HPLC method is developed, and after the purification run the isolated compound is confirmed by NMR and delivered with a CoA documenting purity above 95%.
Beyond preparative purification, the team offers a range of analytical services that can be requested independently or as part of a combined project:
The standard target is above 95% purity. Higher purity requirements can be discussed at the project evaluation stage, depending on matrix complexity and the intended use of the purified material.
Timelines depend on the complexity of the separation and the characterisation scope agreed. Where concept testing is recommended, timing is confirmed during the technical evaluation stage. Full purification projects are scoped individually at the evaluation stage, and a timeline is provided with the initial quote.
Yes. A confidentiality agreement is signed before any technical discussion. Clients working with proprietary compounds or unpublished structures can request NDA terms at the initial enquiry stage.
Yes. Purification for standard development is one of the established applications of the service. Purified material can be further characterised by qNMR to assign purity values, with a CoA documenting the analytical basis for those values.
Useful information includes: compound name or structure, matrix, known solubility and stability data, quantity of starting material available, purity target, and intended downstream use.
Add references to your quote as you browse, or contact our team to discuss your analytical requirements.
