CRMs

The accuracy of an analytical measurement is defined as the closeness of agreement between a test or measurement result and the true value. It usually requires calibration of the analytical method with a known standard. This is often done with standards of several concentrations to make a calibration or working curve.

The highest degree of confidence is achieved with Certified Reference Materials (CRMs), which are characterized by a metrologically valid procedure for one or more specified properties, accompanied by a certificate that provides the value of the specified property, its associated uncertainty, and a statement of metrological traceability, according to the definition stated in ISO Guide 30.

Cifga is the unique lab in the world with ISO 17034 accreditation as reference materials producer in marine biotoxins scope!

ENAC-accredited producer

Nº 2/PMR003
Catalogue

7-O-Palmitoyl Okadaic Acid

CRM-02-DTX3a
Conc.(7.97 ± 0.58) µg/g
Purity≥ 97 %

Azaspiracid-1

CRM-02-AZA1
Conc.[AZA1+37-epi-AZA1] = (1.40± 0.14) µg/g
Purity≥ 99%

Azaspiracid-2

CRM-02-AZA2
Conc.[AZA2+37-epi-AZA2] = (1.62± 0.12) µg/g
Purity≥ 99%

Azaspiracid-3

CRM-02-AZA3
Conc.[AZA3+37-epi-AZA3] = (1.32± 0.12) µg/g
Purity≥ 98%

Decarbamoylgonyautoxins 2 & 3

CRM-00-dcGTX2&3
Conc.[dcGTX2] = (21.9± 1.7) µg/g [dcGTX3] = (8.1± 0.8) µg/g
Purity≥ 97%

Decarbamoylneosaxitoxin

CRM-00-dcNEO
Conc.[dcNEO] = (8.97 ± 0.95) µg/g
Purity≥ 97%

Decarbamoylsaxitoxin

CRM-00-dcSTX
Conc.[dcSTX] = (18.7 ± 1.7) µg/g
Purity≥ 99%

Dinophysistoxin-1

CRM-00-DTX1
Conc.(8.85 ± 0.53) µg/g
Purity≥ 96.0%

Dinophysistoxin-2

CRM-02-DTX2
Conc.(5.2 ± 0.4) µg/g
Purity≥ 99.0%

Domoic Acid

CRM-02-DA
Conc.(102.5 ± 8.2) µg/g
Purity≥98%

Gonyautoxin 5

CRM-00-GTX5
Conc.[GTX5] = (20.2 ± 1.4) µg/g
Purity≥99%

Gonyautoxin 6

CRM-00-GTX6
Conc.[GTX6] = (10.3 ± 0.9) µg/g
Purity≥97%

Gonyautoxin-1 and Gonyautoxin-4

CRM-00-GTX1&4
Conc.[GTX1] = (33.8 ± 2.4) µg/g [GTX4] = (8.0 ± 0.7) µg/g
Purity> 99%

Gonyautoxins 2 & 3

CRM-00-GTX2&3
Conc.[GTX2] = (24.8 ± 1.7) µg/g [GTX3] = (8.0 ± 0.7) µg/g
Purity≥99%

Homoyessotoxin

CRM-00-hYTX
Conc.(8.05 ± 0.60) µg/g
Purity≥99%

N-sulfocarbamoyl Gonyautoxins 1 & 4

CRM-00-C3&4
Conc.[C3]=(11.7 ± 1.0) µg/g, [C4]=(3.43 ± 0.33) µg/g
Purity≥ 97%
Application areas

Can't find the exact compound, concentration or matrix?

Custom concentrations, mixed-toxin formulations and contract purification are handled directly by our production team.

Accreditation

ISO 17034 accreditation: what it means for your lab

ISO 17034 is the international standard governing reference material producers. Accreditation requires an independent technical audit by an external accreditation body. It is not a self-declaration. CIFGA is a reference materials producer accredited by ENAC (Nº 2/PMR003) for a defined scope of marine biotoxins.

In practice, every CRM in the accredited listing carries a certified value traceable to SI units, with certified value determined by NMR and measurement uncertainty supported by homogeneity and stability studies using HPLC-MS/MS. For laboratories operating under ISO 17025, using a CRM from an accredited producer is the most auditable approach available.

Independently audited — not a self-declaration
Metrological traceability — source to certificate
01
Biological source

Produced from natural biological sources using biotechnological processes.

02
In-house purification

Primary production — no redistribution of third-party materials.

03
Certified value by NMR

Determined in-house, traceable to SI units.

04
Homogeneity & stability

Measurement uncertainty supported by HPLC-MS/MS, UV and fluorescence studies.

05
Certificate of Analysis

Certified value and uncertainty, defensible under ISO 17025 audit.

Intra-EU dispatch, no customs delays
Working with CIFGA

Working with CIFGA

CIFGA supplies laboratories in over 40 countries. Shipping from Lugo means intra-EU deliveries carry no customs complications and arrive faster than equivalent shipments from North American suppliers, which is relevant for the significant volume of shellfish monitoring conducted under EU regulatory frameworks.

Custom requirements, including specific concentrations, mixed-toxin formulations, and contract purification, are handled through our tailored services, with technical support provided directly by the production and characterisation team.

Related materials

Related analytical standards and reference materials

Explore the full range of solutions we produce, from marine biotoxins to contract purification services.

Application areas

Quality controlled standards and test kits for laboratories running chemical testing on textiles and garments according to REACH restrictions and recognised ISO methods.

Application areas

Bespoke mixtures, on-demand concentrations and contract purification, developed by CIFGA’s analytical production team.

Research workflows rarely fit a standard catalogue. A method under development may need a mixture of analytes at ratios that do not exist commercially. A validation study may require a concentration outside the available range. A novel compound may need isolation and characterisation before it can be used as a working standard.

These are the situations CIFGA’s tailored services are built for. Using CIFGA’s biotechnology production infrastructure and analytical expertise, we design and produce custom standards, bespoke mixtures and on-demand analytical solutions to meet the specific requirements of your laboratory.

Application areas

The batches obtained for standards defined as Quality Controlled Standards (QCSs) do not allow carrying out all the study requirements due to the limited size. However, they have been developed following the guidelines of ISO Guides Series 30, and the analytical method for quantification and assignment of purity is liquid chromatography coupled to ESI-MS/MS.

Application areas

Analytical standards and contract services for pharmaceutical quality control, produced at our facility in Lugo, Spain and supplied to laboratories in over 40 countries.

Application areas

Accurate mycotoxin analysis starts with the reference material behind it. CIFGA designs and produces Quality Control Standards and Certified Reference Materials for mycotoxin testing, certifying CRMs through a production process with full metrological traceability from source to Certificate of Analysis. A focused catalogue from a European primary producer.

Application areas

This section includes those materials standing for the matrixes where the analytes of interest are usually present. It has been designed to check the behavior of the matrix with your method of analysis.

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